Co-expression of CMTM6 and PD-L1: a novel prognostic indicator of gastric cancer
نویسندگان
چکیده
Abstract Background CKLF Like MARVEL Transmembrane Domain Containing 6 (CMTM6) is involved in the epigenetic regulation of genes and tumorigenesis. Programmed cell death ligand 1 (PD-L1) closely related to prognosis some human cancers. CMTM6 a key regulator PD-L1 many The purpose this study was investigate expressions these proteins gastric cancer correlations with clinicopathological features survival. Methods expression levels were examined 185 specimens using immunohistochemistry, quantitative real-time PCR Western blot. Immunofluorescence used examine localizations PD-L1. Chi-square test analyze relationship between characteristics. Kaplan–Meier method log-rank survival data patients. Results positive rates cancers 78.38% (145/185) 75.68% (140/185), respectively. both mainly expressed membrane nucleus tumor cells. High correlated Borrmann type ( P < 0.001), N stage = 0.002), peritoneal metastasis 0.007) TNM 0.038). tissues showed correlation (Pearson’s coefficient test, r 0.260; 0.001). may positively regulate expression. poor patients (HR 1.668; 95% CI 1.032–2.695; 0.037). be an independent factor for overall 1.554; 1.011–2.389; 0.044). Conclusion combined detection as indicator judging
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ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2021
ISSN: ['1475-2867']
DOI: https://doi.org/10.1186/s12935-020-01734-6